Thanks to a fruitful collaboration with the Weinberg Laboratory at the Whitehead Institute, we are pleased to have played a part in describing these new ovarian cancer models, that were derived from transformed Fallopian tube epithelium, bear human-relevant mutational genotypes, and can grow in immuno-competent C57BL6 mice. These will be an invaluable tool to test novel immunotherapies, and already allowed us to identify Follistatin overexpression as a mechanism of immunotherapy resistance!

The paper is out in Cancer Discovery.